Activating mutations in SHP-2 tyrosine phosphatase implicated in cell signaling processes have been identified in various childhood leukemias and spor Show moreActivating mutations in SHP-2 tyrosine phosphatase implicated in cell signaling processes have been identified in various childhood leukemias and sporadic solid tumors. However, the molecular mechanisms by which the activating mutations in SHP-2 induce malignancies are not fully understood. In this study, we investigated potential involvement of SHP-2 in chromosome segregation during mitosis, dysregulation of which leads to genome instability and malignancies. We determined localization of SHP-2 in the kinetochore, a crucial protein complex structure connecting microtubules and chromosomes. We found that SHP-2 localized at the kinetochore. Our findings suggest that SHP-2 may be involved in chromosome segregation and can help to answer how SHP-2 mutations can induce genetic instability and thereby malignancies. Show less
