<span>Inefficient knowledge transfer in biomedical sciences impacts quality and cost of healthcare while increasing economic burden. Such is of tremendous interest to society and practitioner scholars alike as we are encountering the situation where less physician scientists are entering this system making them ?endangered? due to the challenging crossroads they experience in this journey. In this study, we hope to obtain a deeper understanding of the challenges by determining factors that influence physician scientist lived experiences. How and to what extent do experience, motivation & skills, education & training, environment and institutional mission impact their </span><span>role performance regarding knowledge creation, transfer and evolution of clinical care? Evidence existed for these factors and five additional factors emerged (i.e., social & family impact, phase transitions, team interaction, trusting relationships within an experiential backdrop that is best defined as a Hegelian dialectic) from this qualitative grounded theory study. We postulate that the five emergent themes impact life satisfaction and role performance within the context of Academic Medical Centers which facilitates scientific knowledge transfer to the practice of medicine, benefiting patients, while also stimulating economic growth.Doctorate of Management Programs</span>
