<span>Human motor function is dependent on neuromuscular junction that links nerve system and muscular tissues. The integrity of neuromuscular junction is impaired in many human diseases including amyotrophic lateral sclerosis (ALS), which is well known as the ALS Ice Bucket Challenge. The pathogenesis of ALS is not well understood and there is no cure for this fatal disease. Presented above is a confocal image revealing the structure of neuromuscular junction of </span><span>transversus abdominis muscle isolated from ALS transgenic mouse. Tissue section was stained using mouse anti-neurofilaments antibody (green) to show nerve fibers in muscle. Nicotinic acetylcholine receptors, which are presynaptic marker to transmit nervous signal to muscular tissues, were stained by dye conjugated bungarotoxin (red). The specimen was imaged with a 40x air objective using spinning disk confocal. Author's seal is presented in Chinese in lower right.</span>

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